HOMER1A restores sevoflurane-induced cognitive dysfunction by regulating microglia's activation through activating the AMPK/TXNIP axis

More and more researchers have discovered that the employment of anesthetics can lead to cognitive dysfunction brain. HOMER1A has been investigated neuroprotective effects. Sevoflurane (SEV) is most common inhaled anesthetic utilized in surgery, but role SEV-induced unclear. Thus, this study, SEV was our study for investigating HOMER1A. At first, rat model established through inhaling 2% SEV. Results from uncovered brain tissues SEV-treated rats were severely damaged, levels S-100β neuron-specific enolase (NSE) markedly elevated after treatment. Further showed exhibited lower expression SEV-mediated rats. In addition, ameliorated nerve injury deficit Moreover, improved inflammation suppressed SEV-stimulated microglial activation modulating M1/M2 polarization. Besides, activated Adenosine 5’-monophosphate (AMP)-activated protein kinase (AMPK) pathway reduce thioredoxin interacting (TXNIP) expression. Finally, rescue assays, inhibition AMPK (Compound C (CC) treatment) attenuated effects SEV-triggered summary, regulated microglia polarization restore activating AMPK/TXNIP axis.